subgxe: Combine Multiple GWAS by Using Gene-Environment Interactions
Classical methods for combining summary data from genome-wide
association studies (GWAS) only use marginal genetic effects and power can
be compromised in the presence of heterogeneity. 'subgxe' is a R package
that implements p-value assisted subset testing for association (pASTA),
a method developed by Yu et al. (2019) <doi:10.1159/000496867>. pASTA
generalizes association analysis based on subsets by incorporating
gene-environment interactions into the testing procedure.
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